Profhilo & skin boosters
Hyaluronic acid that spreads through the skin for more hydration, glow and firmness, without changing your face.
from€259
Skin quality
Polynucleotides in Rotterdam
Polynucleotides are purified DNA fragments, usually derived from salmon or trout, injected into the skin to support its natural repair capacity. They are mainly used for thin or tired-looking skin under the eyes, fine lines and better overall skin quality. At Zalat Clinics in Rotterdam, BIG-registered doctor Dr. Pravesh Gadjradj performs the treatment personally.
- Treatment time
- 20–30 minutes
- Results visible
- gradually, after 4–8 weeks and a course of several sessions
- Results last
- on average 6–9 months after a course
- Downtime
- small bumps and redness for 1–2 days, sometimes a bruise
- Price
- from €229
What are polynucleotides?
Polynucleotides are chains of nucleotides, the building blocks of DNA. For aesthetic treatments they are extracted from fish and highly purified. Research suggests that in the skin they support the activity of fibroblasts, the cells that produce collagen and elastin. They also bind moisture. The aim is not to add volume, but to make the skin itself firmer, thicker and more even.
Because polynucleotides do not add volume, they are particularly suited to delicate areas such as the skin under the eyes, where a filler is not always appropriate. The result develops gradually and is subtle: a fresher, more rested look rather than a visible change. It is a relatively new treatment; the scientific evidence is growing but is still more limited than for hyaluronic acid, for example.
Who is it suitable for?
The treatment is suitable for adults aged 18 and over who want to improve their skin quality. If you are allergic to fish or seafood, always let us know; in that case the treatment is not suitable. Also not during pregnancy or breastfeeding.
- Thin, crêpey or dark skin under the eyes
- Fine lines and tired, dull skin
- Less firm skin on the neck or décolletage
- Supporting the skin after past sun damage
What happens during the treatment?
- 01
Free consultation
The doctor assesses your skin, discusses your expectations and checks for allergies. You receive a fixed price for the course in advance.
- 02
Treatment
After cleansing, the product is placed in small amounts in the skin with a fine needle or cannula. A session takes about 20–30 minutes.
- 03
Course
Usually 3 sessions are given, 2–4 weeks apart. The skin improves gradually during and after the course.
- 04
Free check-up after two weeks
The doctor checks how your skin is responding and plans the next steps with you.
Aftercare and possible side effects
Small bumps, redness and mild swelling after treatment are normal and usually disappear within 1–2 days. A bruise can occur, especially under the eyes. Serious side effects are rare. For that reason, it is best not to schedule treatment just before an important event. If you have questions you can reach the doctor via WhatsApp.
- Do not apply make-up to the treated skin for the first 12 hours
- Avoid exercise, sauna and sunbeds for 24 hours
- Use daily sun protection to support the result
How much do polynucleotides cost?
Polynucleotide treatment costs from €229 per session. Because a course of three sessions is usually advised, we discuss the total cost in advance. The final price is agreed during the consultation. The consultation and the two-week check-up are free.
Medically reviewed by Dr. Pravesh Gadjradj, BIG 39924163701.
Frequently asked questions
Are polynucleotides the same as a skin booster?
They are often grouped together, but they work differently. A hyaluronic acid skin booster mainly hydrates, while polynucleotides aim to support the skin's repair processes.
How many treatments are needed?
Usually 3 sessions, 2–4 weeks apart. After that, maintenance once or twice a year is common.
Can I have polynucleotides if I am allergic to fish?
No. Because the product is derived from fish, we do not treat people with a fish or seafood allergy. Always mention this during the consultation.
Do polynucleotides help with dark circles?
They can make thin, translucent skin under the eyes firmer, so dark circles become less noticeable in some people. Circles caused by pigmentation or genetics usually do not disappear completely.
Related treatments
Biostimulators (Radiesse, Sculptra)
Radiesse and Sculptra prompt the skin to produce its own collagen, for gradually firmer skin and a natural-looking result.
from€350
Ready for the first step?
Book a no-obligation consultation. We take time for your questions, and you know exactly what to expect before anything is done.